Canada

Innovative randomized trial hints at mortality benefits with high-dose flu vaccines

Notes to the editor

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Acknowledgments: The lead author and presenter of the trial results was Dr. Niklas Dyrby Johansen, Center for Translational Cardiology and Pragmatic Randomized Trials, University of Copenhagen, Denmark.

Funding: The study was funded by Sanofi, who provided the high-dose vaccines for the study and a financial contribution to the remaining costs.

Disclosures: JN was previously employed by Sanofi and may own stock and/or stock options in the company. SS, CS, and MML are full-time employees of Sanofi and may own stock and/or stock options in the company. CSL is Chief Medical Officer at Danske Lægers Vaccinations Service, part of the European LifeCare Group, and has received speaker fees and served on advisory boards for GSK, MSD, Pfizer, Takeda and Valneva. BLC has received consulting fees from Amgen, Cardurion, Corvia, Myokardia, and Novartis. SDS has received research grants from Actelion, Alnylam, Amgen, AstraZeneca, Bellerophon, Bayer, BMS, Celladon, Cytokinetics, Eidos, Gilead, GSK, Ionis, Lilly, Mesoblast, MyoKardia, NIH/NHLBI, Neurotronik, Novartis, Novo Nordisk , Respicardia , Sanofi, Theracos, US2.AI and consulted for Abbott, Action, Akros, Alnylam, Amgen, Arena, AstraZeneca, Bayer, Boehringer Ingelheim, BMS, Cardior, Cardurion, Corvia, Cytokinetics, Daiichi-Sankyo, GSK, Lilly, Merck, Myokardia, Novartis, Roche, Theracos, Quantum Genomics, Cardurion, Janssen, Cardiac Dimensions, Tenaya, Sanofi, Dinaqor, Tremeau, CellProThera, Moderna, American Regent, Sarepta, Lexicon, Anacardio, Akros and Puretech Health. LK has received speaker honoraria from Novo Nordisk, Novartis, AstraZeneca, Boehringer Ingelheim, and Bayer. TB-S served as a steering committee member of the Amgen-funded GALACTIC-HF trial and the Boston Scientific-funded LUX-Dx TRENDS trial, served on advisory boards for Sanofi and Amgen, received speaker honoraria from Novartis and Sanofi Pasteur, and has received research grants from GE Healthcare and Sanofi Pasteur. All other authors declare no competing interests.

References and notes

1DANFLU-1 will be discussed during:

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